4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile

Base Information

Chemical Name:4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile
CAS No.:268548-74-9
Molecular Formula:C26H24 N4
Molecular Weight:392.49556
Hs Code.:
DSSTox Substance ID:DTXSID20405230
Mol file:268548-74-9.mol

Synonyms:4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile;268548-74-9;2-amino-4-(3-tritylimidazol-4-yl)butanenitrile;DTXSID20405230;AKOS030255773;FT-0675691;J-016572

Suppliers and Price of 4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile
250mg
$ 1320.00

TRC
4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile
100mg
$ 605.00

Medical Isotopes, Inc.
4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile
0.5 g
$ 1720.00

American Custom Chemicals Corporation
4-(1-TRITYLIMIDAZOL-4-YL)-2-AMINOBUTRYONITRILE 95.00%
2.5G
$ 2035.00

American Custom Chemicals Corporation
4-(1-TRITYLIMIDAZOL-4-YL)-2-AMINOBUTRYONITRILE 95.00%
250MG
$ 750.75

Total 2 raw suppliers

Chemical Property of 4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile

Chemical Property:

Vapor Pressure:2.44E-13mmHg at 25°C
Melting Point:111-113°C
Refractive Index:1.621
Boiling Point:577.6°C at 760 mmHg
PKA:6.40±0.33(Predicted)
Flash Point:303.1°C
PSA：67.63000
Density:1.11g/cm³
LogP:5.20708
Storage Temp.:-20°C Freezer
Solubility.:DMF, Ethyl Acetate, Methanol
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:392.20009678
Heavy Atom Count:30
Complexity:517

Purity/Quality:

98%Min ^*data from raw suppliers

4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=NC=C4CCC(C#N)N
Uses 4-(1-TRITYLIMIDAZOL-4-YL)-2-AMINOBUTRYONITRILE is used in synthesis of (+/-)-homohistidine.

Technology Process of 4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile

There total 5 articles about 4-(1-Tritylimidazol-4-yl)-2-aminobutryonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 151-50-8
potassium cyanide

: 186096-23-1
3-(1-tritylimidazol-4-yl)propionaldehyde

: 268548-74-9
4-(1-tritylimidazol-4-yl)-2-aminobutyronitrile

Guidance literature:: 3-(1-tritylimidazol-4-yl)propionaldehyde; With ammonium hydroxide; ammonium chloride; In methanol; at 20 ℃; for 0.666667h;

potassium cyanide; at 20 ℃; for 18h; Further stages.;
DOI:10.1021/jo991630q

Reference yield:

: 70346-51-9
methyl (E)-3-(1H-imidazol-5-yl)prop-2-enoate

: 268548-74-9
4-(1-tritylimidazol-4-yl)-2-aminobutyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / H₂ / Pd/C / methanol / 20 °C

2.1: 92 percent / Et₃N / dimethylformamide / 20 °C

3.1: 100 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / -78 °C

4.1: aq. NH₃; NH₄Cl / methanol / 0.67 h / 20 °C

4.2: 84 percent / 18 h / 20 °C

With ammonium hydroxide; hydrogen; diisobutylaluminium hydride; ammonium chloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Catalytic hydrogenation / 2.1: Substitution / 3.1: Reduction / 4.1: Addition / 4.2: Condensation;
DOI:10.1021/jo991630q

Reference yield:

: 3465-72-3
(E)-3-(1H-imidazol-4-yl)propenoic acid

: 268548-74-9
4-(1-tritylimidazol-4-yl)-2-aminobutyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / Na₂SO₄; conc. h2SO₄ / 30 h / Heating

2.1: 96 percent / H₂ / Pd/C / methanol / 20 °C

3.1: 92 percent / Et₃N / dimethylformamide / 20 °C

4.1: 100 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / -78 °C

5.1: aq. NH₃; NH₄Cl / methanol / 0.67 h / 20 °C

5.2: 84 percent / 18 h / 20 °C

With ammonium hydroxide; sulfuric acid; hydrogen; diisobutylaluminium hydride; ammonium chloride; sodium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Esterification / 2.1: Catalytic hydrogenation / 3.1: Substitution / 4.1: Reduction / 5.1: Addition / 5.2: Condensation;
DOI:10.1021/jo991630q