(+/-)-Homohistidine

Base Information

Chemical Name:(+/-)-Homohistidine
CAS No.:5817-77-6
Molecular Formula:C7H11N3O2
Molecular Weight:169.18
Hs Code.:2933290090
DSSTox Substance ID:DTXSID40399985
ChEMBL ID:CHEMBL3272401
Mol file:5817-77-6.mol

Synonyms:(+/-)-Homohistidine;5817-77-6;2-amino-4-(1H-imidazol-5-yl)butanoic acid;L-Homohistidine;SCHEMBL951906;CHEMBL3272401;DTXSID40399985;AKOS006278302;AKOS030242490;2-amino-4-(1H-imidazol-4-yl)butanoic acid;FT-0669229;FT-0669230

Suppliers and Price of (+/-)-Homohistidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(+/-)-Homohistidine
250mg
$ 1390.00

Medical Isotopes, Inc.
(+/-)-Homohistidine
0.5 g
$ 1800.00

Medical Isotopes, Inc.
(+/-)-Homohistidine
100 mg
$ 850.00

American Custom Chemicals Corporation
(+/-)-HOMOHISTIDINE 95.00%
100MG
$ 716.10

American Custom Chemicals Corporation
(+/-)-HOMOHISTIDINE 95.00%
10MG
$ 411.60

American Custom Chemicals Corporation
(+/-)-HOMOHISTIDINE 95.00%
1G
$ 1686.30

AccelPharmtech
a-amino-1H-Imidazole-5-butanoicacid 97.00%
25G
$ 11400.00

AccelPharmtech
a-amino-1H-Imidazole-5-butanoicacid 97.00%
5G
$ 6050.00

AccelPharmtech
a-amino-1H-Imidazole-5-butanoicacid 97.00%
1G
$ 3510.00

Total 5 raw suppliers

Chemical Property of (+/-)-Homohistidine

Chemical Property:

Melting Point:242-244°C
PSA：92.00000
LogP:0.45450
Storage Temp.:-20°C Freezer
Solubility.:Methanol, Water
XLogP3:-2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:169.085126602
Heavy Atom Count:12
Complexity:163

Purity/Quality:

99% ^*data from raw suppliers

(+/-)-Homohistidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(NC=N1)CCC(C(=O)O)N
Uses (+/-)-Homohistidine is used for the study of histidine kinases as a support for solid phase synthesis.

Technology Process of (+/-)-Homohistidine

There total 7 articles about (+/-)-Homohistidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70346-51-9
methyl (E)-3-(1H-imidazol-5-yl)prop-2-enoate

: 5817-77-6
homohistidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / H₂ / Pd/C / methanol / 20 °C

2.1: 92 percent / Et₃N / dimethylformamide / 20 °C

3.1: 100 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / -78 °C

4.1: aq. NH₃; NH₄Cl / methanol / 0.67 h / 20 °C

4.2: 84 percent / 18 h / 20 °C

5.1: conc. HCl / Heating

With hydrogenchloride; ammonium hydroxide; hydrogen; diisobutylaluminium hydride; ammonium chloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Catalytic hydrogenation / 2.1: Substitution / 3.1: Reduction / 4.1: Addition / 4.2: Condensation / 5.1: Hydrolysis;
DOI:10.1021/jo991630q

Reference yield:

: 3465-72-3
(E)-3-(1H-imidazol-4-yl)propenoic acid

: 5817-77-6
homohistidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / Na₂SO₄; conc. h2SO₄ / 30 h / Heating

2.1: 96 percent / H₂ / Pd/C / methanol / 20 °C

3.1: 92 percent / Et₃N / dimethylformamide / 20 °C

4.1: 100 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / -78 °C

5.1: aq. NH₃; NH₄Cl / methanol / 0.67 h / 20 °C

5.2: 84 percent / 18 h / 20 °C

6.1: conc. HCl / Heating

With hydrogenchloride; ammonium hydroxide; sulfuric acid; hydrogen; diisobutylaluminium hydride; ammonium chloride; sodium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Esterification / 2.1: Catalytic hydrogenation / 3.1: Substitution / 4.1: Reduction / 5.1: Addition / 5.2: Condensation / 6.1: Hydrolysis;
DOI:10.1021/jo991630q

Reference yield:

: 31434-93-2
methyl 3-(1H-imidazol-5-yl)propanoate

: 5817-77-6
homohistidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / Et₃N / dimethylformamide / 20 °C

2.1: 100 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / -78 °C

3.1: aq. NH₃; NH₄Cl / methanol / 0.67 h / 20 °C

3.2: 84 percent / 18 h / 20 °C

4.1: conc. HCl / Heating

With hydrogenchloride; ammonium hydroxide; diisobutylaluminium hydride; ammonium chloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Substitution / 2.1: Reduction / 3.1: Addition / 3.2: Condensation / 4.1: Hydrolysis;
DOI:10.1021/jo991630q