Technology Process of (5R,8RS)-5-methyl-8-phenylsulfonylheptacosane
There total 9 articles about (5R,8RS)-5-methyl-8-phenylsulfonylheptacosane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-4-methyl-1-phenylsulfonyloctane;
With
n-butyllithium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -30 ℃;
for 0.25h;
nonadecyl iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at 20 ℃;
for 12h;
DOI:10.1271/bbb.65.305
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine
2.1: 4.59 g / Li2CuCl4 / tetrahydrofuran / 12 h / -78 - 4 °C
3.1: O3 / methanol; CH2Cl2 / 6 h / -78 °C
3.2: 65 percent / NaBH4 / methanol; CH2Cl2 / 3 h / -78 - 0 °C
4.1: 4.26 g / pyridine / CHCl3 / 12 h / 4 °C
5.1: 2.65 g / NaI; NaHCO3 / acetone / 4 h / Heating
6.1: 89 percent / dimethylformamide / 12 h / 20 °C
7.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -30 °C
7.2: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 12 h / 20 °C
With
pyridine; n-butyllithium; dilithium tetrachlorocuprate; sodium hydrogencarbonate; ozone; sodium iodide;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1271/bbb.65.305
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 99 percent / pyridine / CHCl3 / 12 h / 4 °C
2.1: 88 percent / NaI NaHCO3 / acetone / 2 h / Heating
3.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -30 °C
3.2: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 12 h / 20 °C
With
pyridine; n-butyllithium; sodium hydrogencarbonate; sodium iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; chloroform; acetone;
DOI:10.1271/bbb.65.305
