N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

Base Information

Chemical Name:N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide
CAS No.:1491169-42-6
Molecular Formula:C₂₇H₁₇F₇N₂O₃S
Molecular Weight:582.498
Hs Code.:

Synonyms:N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

Chemical Property:

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Technology Process of N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

There total 7 articles about N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1491169-37-9
N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

: 98-88-4
benzoyl chloride

: 1491169-42-6
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

Guidance literature:: N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

benzoyl chloride; With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1491168-99-0
ethyl 4-(2-fluorophenyl)nicotinate

: 1491169-42-6
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

3.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

4.1: hydrogenchloride

5.1: triethylamine / dichloromethane / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1491169-42-6
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 12 h / 85 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

4.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

5.1: hydrogenchloride

6.1: triethylamine / dichloromethane / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

7.2: 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling / 4.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050