(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

Base Information

Chemical Name:(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester
CAS No.:1329167-75-0
Molecular Formula:C₃₅H₄₈N₄O₇Si
Molecular Weight:664.874
Hs Code.:

(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

Synonyms:(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

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Chemical Property of (S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

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Technology Process of (S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

There total 1 articles about (S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1329167-53-4
(S)-3-[4-(2-bromo-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

: 24850-33-7
allyltributylstanane

: 1329167-75-0
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

Guidance literature:: With tri-tert-butyl phosphine; cesium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 5.5h; Inert atmosphere;

Reference yield: 100.0%

: 1329167-75-0
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

: 1329167-76-1
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid

Guidance literature:: (S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 1329167-75-0
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

: 1329167-77-2
{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

1.2: pH 5

2.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;