{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Base Information

Chemical Name:{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester
CAS No.:1329167-77-2
Molecular Formula:C₃₂H₄₉N₅O₆Si
Molecular Weight:627.856
Hs Code.:

{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Synonyms:{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

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Chemical Property of {3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

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Technology Process of {3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

There total 3 articles about {3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 627-37-2
N-methyl-N-allylamine

: 1329167-76-1
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid

: 1329167-77-2
{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1329167-53-4
(S)-3-[4-(2-bromo-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

: 1329167-77-2
{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5.5 h / 90 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

2.2: pH 5

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With tri-tert-butyl phosphine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; cesium fluoride; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1329167-75-0
(S)-3-[4-(2-allyl-4-methoxycarbonylaminophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-2-yl]-3-tert-butoxycarbonylaminopropionic acid benzyl ester

: 1329167-77-2
{3-allyl-4-[2-[(S)-2-(allyl-methyl-carbamoyl)-1-tert-butoxycarbonylaminoethyl]-1-(2-trimethylsilanylethoxymethyl)-1H-imidazol-4-yl]phenyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

1.2: pH 5

2.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;