4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

Base Information

Chemical Name:4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester
CAS No.:1266116-20-4
Molecular Formula:C₂₉H₄₃NO₃
Molecular Weight:453.665
Hs Code.:

Synonyms:4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

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Chemical Property of 4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

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Technology Process of 4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

There total 8 articles about 4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1266115-60-9
6-(trans-4-tert-butylcyclohexyloxy)-2-naphthaldehyde

: tert-butyl 4-aminobutanoate hydrochloride

: 1266116-20-4
4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266116-20-4
4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

2.3: pH 6

3.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane; butanone; tert-butyl alcohol;

Reference yield:

: 17295-11-3
methyl 6-hydroxynaphthalene-2-carboxylate

: 1266116-20-4
4-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 6 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;