3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

Base Information

Chemical Name:3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one
CAS No.:1044871-80-8
Molecular Formula:C₂₆H₃₃N₃O₄
Molecular Weight:451.566
Hs Code.:

Synonyms:3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

There total 14 articles about 3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1044872-19-6
3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

: 1044871-80-8
3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

Guidance literature:: With ammonia; In ethanol; at 130 ℃; for 16h;

Reference yield:

: 4778-99-8
2-carboxymethyl-4,6-dimethoxy-benzoic acid

: 1044871-80-8
3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride / toluene / 2 h / Reflux

2.1: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

2.2: 2 h / 100 °C

2.3: 6 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

3.2: 16 h / 80 °C

4.1: triethylamine / dimethyl sulfoxide / 16 h / 110 °C

5.1: ammonia / ethanol / 16 h / 130 °C

With ammonia; acetic anhydride; sodium hydride; triethylamine; N,N,N',N'-tetramethylguanidine; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 6512-32-9
methyl 2-(3,5-dimethoxyphenyl)acetate

: 1044871-80-8
3-(3,5-dimethyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 20 - 100 °C

2.1: dihydrogen peroxide; sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile / 4 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

4.1: acetic anhydride / toluene / 2 h / Reflux

5.1: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

5.2: 2 h / 100 °C

5.3: 6 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

6.2: 16 h / 80 °C

7.1: triethylamine / dimethyl sulfoxide / 16 h / 110 °C

8.1: ammonia / ethanol / 16 h / 130 °C

With sodium chlorite; sodium dihydrogenphosphate; ammonia; water; dihydrogen peroxide; acetic anhydride; sodium hydride; triethylamine; sodium hydroxide; trichlorophosphate; N,N,N',N'-tetramethylguanidine; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;