3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

Base Information

Chemical Name:3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one
CAS No.:1044872-19-6
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

There total 12 articles about 3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 109-01-3
1-methyl-piperazine

: 924300-56-1
3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

: 1044872-19-6
3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 110 ℃; for 16h;

Reference yield: 17.0%

: 924300-56-1
3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

: 1044872-19-6
3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: With 1-methyl-piperazine; triethylamine; In dimethyl sulfoxide; at 110 ℃; for 16h;

Reference yield:

: 4919-37-3
3,5-dimethyl-4-hydroxybenzoic acid

: 1044872-19-6
3-[3,5-dimethyl-4-(2-(4-methyl piperazin-1-yl)-ethoxy)-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 4 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

3.2: 2 h / 100 °C

3.3: 6 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

4.2: 16 h / 80 °C

5.1: triethylamine / dimethyl sulfoxide / 16 h / 110 °C

With pyridine; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; N,N,N',N'-tetramethylguanidine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;