(2-Methylenecyclohexyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:(2-Methylenecyclohexyl)carbamic acid tert-butyl ester
CAS No.:267668-38-2
Molecular Formula:C₁₂H₂₁NO₂
Molecular Weight:211.304
Hs Code.:
DSSTox Substance ID:DTXSID701171114
Nikkaji Number:J1.323.333K
Mol file:267668-38-2.mol

Synonyms:DTXSID701171114;267668-38-2;(2-Methylenecyclohexyl)carbamic acid tert-butyl ester;Carbamic acid, (2-methylenecyclohexyl)-, 1,1-dimethylethyl ester

Suppliers and Price of (2-Methylenecyclohexyl)carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2-Methylenecyclohexyl)carbamic acid tert-butyl ester

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:211.157228913
Heavy Atom Count:15
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCCCC1=C

Technology Process of (2-Methylenecyclohexyl)carbamic acid tert-butyl ester

There total 4 articles about (2-Methylenecyclohexyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 267668-28-0
N-tert-butyloxycarbonyl-N-(2-methylene cyclohexyl)benzenesulfenamide

: 267668-38-2
N-tert-butoxycarbonyl-N-(2-methylenecyclohexyl)amine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h; Heating;
DOI:10.1021/jo991569p

Reference yield:

: 101704-19-2
1-((phenylthio)methyl)cyclohexanol

: 267668-38-2
N-tert-butoxycarbonyl-N-(2-methylenecyclohexyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: 3.1 g / p-toluenesulfonic acid / benzene / 4 h / Heating

2: 65 percent / FeCl₂ / CH₂Cl₂ / 20 °C

3: 86 percent / Bu₃SnH; AIBN / benzene / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; iron(II) chloride; In dichloromethane; benzene; 1: Elimination / 2: Rearrangement / 3: desulfurization;
DOI:10.1021/jo991569p

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 267668-38-2
N-tert-butoxycarbonyl-N-(2-methylenecyclohexyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0 - 20 °C

1.2: tetrahydrofuran / 2.5 h / 20 °C

2.1: 3.1 g / p-toluenesulfonic acid / benzene / 4 h / Heating

3.1: 65 percent / FeCl₂ / CH₂Cl₂ / 20 °C

4.1: 86 percent / Bu₃SnH; AIBN / benzene / 1 h / Heating

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; iron(II) chloride; In tetrahydrofuran; hexane; dichloromethane; benzene; 1.1: Metallation / 1.2: Addition / 2.1: Elimination / 3.1: Rearrangement / 4.1: desulfurization;
DOI:10.1021/jo991569p