Technology Process of 4-amino-4-deoxy-11-thiohomopteroic acid
There total 9 articles about 4-amino-4-deoxy-11-thiohomopteroic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / sodium azide, potassium iodide / acetone
2: 85 percent / p-toluenesulfonic acid / benzene / 6 h / Heating
3: H2 / 5percent Pd/C / methanol / 18 h / 1189.4 Torr
4: 78 percent / N-methylmorpholine / methanol / 4 h / Heating
5: 94 percent / trifluoroacetic acid (TFA) / 50 °C
6: 80 percent / sodium dithionite / dioxane
7: 750 mg / pyridine, concd. HCl / methanol / 1 h / Heating
8: dimethylformamide / 2 h / 120 °C
9: 240 mg / NaOH / acetonitrile / 4 h
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; sodium azide; sodium dithionite; hydrogen; toluene-4-sulfonic acid; N,N-dimethyl-formamide; trifluoroacetic acid; potassium iodide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; acetone; acetonitrile; benzene;
DOI:10.1021/jm00182a017
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 85 percent / p-toluenesulfonic acid / benzene / 6 h / Heating
2: H2 / 5percent Pd/C / methanol / 18 h / 1189.4 Torr
3: 78 percent / N-methylmorpholine / methanol / 4 h / Heating
4: 94 percent / trifluoroacetic acid (TFA) / 50 °C
5: 80 percent / sodium dithionite / dioxane
6: 750 mg / pyridine, concd. HCl / methanol / 1 h / Heating
7: dimethylformamide / 2 h / 120 °C
8: 240 mg / NaOH / acetonitrile / 4 h
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; toluene-4-sulfonic acid; N,N-dimethyl-formamide; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; acetonitrile; benzene;
DOI:10.1021/jm00182a017
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / 5percent Pd/C / methanol / 18 h / 1189.4 Torr
2: 78 percent / N-methylmorpholine / methanol / 4 h / Heating
3: 94 percent / trifluoroacetic acid (TFA) / 50 °C
4: 80 percent / sodium dithionite / dioxane
5: 750 mg / pyridine, concd. HCl / methanol / 1 h / Heating
6: dimethylformamide / 2 h / 120 °C
7: 240 mg / NaOH / acetonitrile / 4 h
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; N,N-dimethyl-formamide; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm00182a017
