4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester
• CAS No.: 74162-97-3
• Molecular Formula: C₁₄H₁₇N₃O₄S
• Molecular Weight: 323.373

Synonyms:4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester

Chemical Property of 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester

There total 2 articles about 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethylene glycol (107-21-1) + 1-azido-4--2-butanone (74162-96-2) → 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester (74162-97-3)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

DOI:10.1021/jm00182a017

Reference yield:

1-chloro-4--2-butanone (67426-03-3) → 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester (74162-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / sodium azide, potassium iodide / acetone

2: 85 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With sodium azide; toluene-4-sulfonic acid; potassium iodide; In acetone; benzene;

DOI:10.1021/jm00182a017

Reference yield: 99.0%

4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester (74162-97-3) → 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid (74162-98-4)

Guidance literature:

With sodium hydroxide; In acetonitrile; for 6h;

DOI:10.1021/jm00182a017

upstream raw materials:

ethylene glycol

1-azido-4--2-butanone

1-chloro-4--2-butanone

Downstream raw materials:

4-[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester

4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid

4-amino-4-deoxy-11-thiohomopteroic acid

methyl 4-amino-4-deoxy-11-thiohomopteroate

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