R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Base Information

Chemical Name:R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide
CAS No.:1352485-19-8
Molecular Formula:C₃₀H₃₄F₂N₄O₂
Molecular Weight:520.622
Hs Code.:

Synonyms:R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Suppliers and Price of R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

There total 12 articles about R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-(1H-indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

: 84315-23-1
(trans)-3-(3,5-difluorophenyl)acrylic acid

: 1352485-19-8
R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1352485-19-8
R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol / 4 h / 70 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 4 h / 2327.23 Torr

3.1: hydrogenchloride / N,N-dimethyl-formamide; water / 24 h / 30 - 50 °C

4.1: titanium(IV) isopropylate / ethanol / 2 h / 20 °C / Inert atmosphere

4.2: 72 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 50 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 881016-88-2
4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1352485-19-8
R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / Inert atmosphere

3.1: ammonia / methanol / 72 h / 100 °C

4.1: titanium(IV) isopropylate / ethanol / 2 h / 20 °C / Inert atmosphere

4.2: 72 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 50 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; sodium azide; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;