(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester
CAS No.:117085-70-8
Molecular Formula:C₄₆H₄₉N₂O₇P
Molecular Weight:772.878
Hs Code.:

Synonyms:(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

There total 7 articles about (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 117085-70-8
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 °C

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

3: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

4: ethyl acetate / 1.5 h / Ambient temperature

5: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028

Reference yield:

: 126111-16-8
(S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid

: 117085-70-8
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

3: ethyl acetate / 1.5 h / Ambient temperature

4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028

Reference yield:

: 79854-42-5
Ethyl (S)-indoline-2-carboxylate hydrochloride

: 117085-70-8
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature

3: ethyl acetate / 1.5 h / Ambient temperature

4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

With dmap; lithium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028