Boc-D-MeIle-OH

Base Information

Chemical Name:Boc-D-MeIle-OH
CAS No.:267223-87-0
Molecular Formula:C12H23 N O4
Molecular Weight:245.319
Hs Code.:
DSSTox Substance ID:DTXSID00427152
Wikidata:Q72470173
Mol file:267223-87-0.mol

Synonyms:Boc-D-MeIle-OH;267223-87-0;Boc-N-Me-D-Ile-OH;N-(tert-butoxycarbonyl)-N-methyl-D-isoleucine;(2R,3R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylpentanoic acid;(2R,3R)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoic acid;Boc-N-methyl-D-isoleucine;Boc-N-Me-DIle-OH;SCHEMBL1128243;DTXSID00427152;HTBIAUMDQYXOFG-RKDXNWHRSA-N;MFCD00236865;AKOS024259145;FD21822;AS-49212;CS-0316280;N-alpha-(t-Butyloxycarbonyl)-N-alpha-methyl-D-isoleucine;(2R,3R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylpentanoicacid;(2R,3R)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-methylpentanoic acid

Suppliers and Price of Boc-D-MeIle-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-N-methyl-D-isoleucine
50mg
$ 340.00

Iris Biotech GmbH
Boc-D-MeIle-OH
5 g
$ 1620.00

Crysdot
(2R,3R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylpentanoicacid 97%
1g
$ 232.00

ChemPep
Boc-N-Me-D-Ile-OH
1g
$ 280.00

ChemPep
Boc-N-Me-D-Ile-OH
5g
$ 840.00

Chem-Impex
Boc-N-methyl-D-isoleucine,99%(TLC) 99%(TLC)
2.5G
$ 684.32

Chem-Impex
Boc-N-methyl-D-isoleucine,99%(TLC) 99%(TLC)
1G
$ 324.80

Chem-Impex
Boc--methyl-D-isoleucine ≥ 99% (TLC)
100MG
$ 77.60

Chem-Impex
Boc--methyl-D-isoleucine ≥ 99% (TLC)
250MG
$ 145.00

Chemenu
N-(tert-butoxycarbonyl)-N-methyl-D-isoleucine 97%
1g
$ 217.00

Total 12 raw suppliers

Chemical Property of Boc-D-MeIle-OH

Chemical Property:

PSA：66.84000
LogP:2.35260
Storage Temp.:Store at RT.
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:245.16270821
Heavy Atom Count:17
Complexity:283

Purity/Quality:

99% ^*data from raw suppliers

Boc-N-methyl-D-isoleucine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(C(=O)O)N(C)C(=O)OC(C)(C)C
Isomeric SMILES:CC[C@@H](C)[C@H](C(=O)O)N(C)C(=O)OC(C)(C)C
Uses Boc-N-Methyl-D-Isoleucine (cas# 267223-87-0) is used as a reagent in the preparation of dipeptide [(6-aminopyridin-3-yl)methyl]amide derivatives as kallikrein 1 inhibitors.

Technology Process of Boc-D-MeIle-OH

There total 2 articles about Boc-D-MeIle-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55721-65-8
Boc-D-Ile-OH

: 74-88-4
methyl iodide

: 267223-87-0
Boc-N-me-DIle-OH

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 26h; Inert atmosphere;
DOI:10.1021/np5003548

Reference yield:

: 319-78-8,959215-79-3,18875-42-8
D-Isoleucine

: 24424-99-5
di-tert-butyl dicarbonate

: 267223-87-0
Boc-N-me-DIle-OH

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2: sodium hydride / tetrahydrofuran / 26 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; water;
DOI:10.1021/np5003548

Reference yield: 53.0%

: 267223-87-0
Boc-N-me-DIle-OH

: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-dichloro-phenyl)-propionamide dihydrochloride

: 1194096-56-4
{(R)-1-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-2-methyl-butyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Boc-N-me-DIle-OH; (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-dichloro-phenyl)-propionamide dihydrochloride; With benzotriazol-1-ol; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 0.25h; water soluble carbodiimide;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h;