1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

Base Information

Chemical Name:1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine
CAS No.:227778-59-8
Molecular Formula:C₂₁H₂₆N₂O₅
Molecular Weight:386.448
Hs Code.:

Synonyms:1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

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Chemical Property of 1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

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Technology Process of 1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

There total 3 articles about 1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4248-19-5
tert-butyl carbazate

: 227778-58-7
N-benzyloxycarbonyl 3-aminostyrene

: 227778-59-8
1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

Guidance literature:: With osmium(VIII) oxide; (DHQ)2-PHAL; tert-butylhypochlorite; In propan-1-ol; sodium hydroxide; at -5 ℃;
DOI:10.1021/jo982161f

Reference yield:

: 586-39-0,51209-60-0
1-nitro-3-vinyl-benzene

: 227778-59-8
1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Na₂S₂O₄; K₂CO₃; 1,1'-dioctyl-4,4'-bipyridinium bromide / H₂O; CH₂Cl₂ / 8 h / 35 °C

2: 96 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3: 66 percent / OsO₄; t-butyl hypochlorite; (DHQ)2-PHAL / aq. NaOH; propan-1-ol / -5 °C

With 2,6-dimethylpyridine; osmium(VIII) oxide; sodium dithionite; (DHQ)2-PHAL; tert-butylhypochlorite; potassium carbonate; 1,1’-di-n-octyl-4,4’-bipyridinium dibromide; In propan-1-ol; sodium hydroxide; dichloromethane; water; 1: Reduction / 2: Substitution / 3: Addition;
DOI:10.1021/jo982161f

Reference yield:

: 15411-43-5
3-vinylaniline

: 227778-59-8
1(S)-N-[(tert-butyloxy)carbonyl]-1-[3-N-(benzyloxy)carbonylaminophenyl]-2-hydroxyethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

2: 66 percent / OsO₄; t-butyl hypochlorite; (DHQ)2-PHAL / aq. NaOH; propan-1-ol / -5 °C

With 2,6-dimethylpyridine; osmium(VIII) oxide; (DHQ)2-PHAL; tert-butylhypochlorite; In propan-1-ol; sodium hydroxide; dichloromethane; 1: Substitution / 2: Addition;
DOI:10.1021/jo982161f