(1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol

Base Information

• Chemical Name: (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol
• CAS No.: 136768-15-5
• Molecular Formula: C₄₅H₄₀N₂O₄
• Molecular Weight: 672.824
• Mol file: 136768-15-5.mol

Synonyms:(1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol

Chemical Property of (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol

There total 1 articles about (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-C-(1H-imidazol-4-yl)-D-arabino-tetritol hydrochloride + trityl chloride (76-83-5) → (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol (136768-15-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; Ambient temperature; 1) 20 h, 2) CHCl₃, 24 h;

DOI:10.1002/hlca.19910740503

Reference yield: 95.0%

benzyl bromide (100-39-0) + (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol (136768-15-5) → (1R,2S,3R)-1,2,3-tris(benzyloxy)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane (136768-16-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1002/hlca.19910740503

Reference yield: 74.0%

benzyl bromide (100-39-0) + (1R,2S,3R)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane-1,2,3-triol (136768-15-5) → (2R,3S,4R)-3,4-bis(benzyloxy)-4-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>-1-(triphenylmethoxy)butan-2-ol (136768-19-9)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at -5 ℃; for 24h;

DOI:10.1002/hlca.19910740503

upstream raw materials:

trityl chloride

Downstream raw materials:

(2R,3S,4R)-3,4-bis(benzyloxy)-4-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>-1-(triphenylmethoxy)butan-2-ol

(1R,2S,3R)-1,2,3-tris(benzyloxy)-4-(triphenylmethoxy)-1-<1'-(triphenylmethyl)-1'H-imidazol-4'-yl>butane

(5S,6R,7R)-6,7-bis(benzyloxy)-6,7-dihydro-5H-pyrrolo<1,2-c>imidazol-5-methanol

(2R,3S,4R)-3,4-bis(benzyloxy)-4-<1'H-imidazol-4'-yl>butane-1,2-diol