(6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone

Base Information

• Chemical Name: (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone
• CAS No.: 1254339-50-8
• Molecular Formula: C₁₈H₁₄Cl₂O₆
• Molecular Weight: 397.212

Synonyms:(6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone

Chemical Property of (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone

Chemical Property:

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Technology Process of (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone

There total 2 articles about (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3-dichloro-1,4-benzoquinone (5145-42-6) + 3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (10078-54-3) → (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone (1254339-50-8)

Guidance literature:

With Amberlyst-15in PEG 400; at 20 ℃; for 0.25h; Green chemistry;

DOI:10.2174/1570178614666170329151935

Reference yield:

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → (6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone (1254339-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 20 h / 150 °C / Inert atmosphere

2: acetic acid / 5 h / 20 °C / Inert atmosphere

With acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.05.129

Reference yield: 49.0%

(6,7dichloro-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone (1254339-50-8) → 6,7-dichloro-3-(3,4,5-trimethoxy-benzoyl)-benzofuran-4,5-dione (1254339-54-2)

Guidance literature:

With nitric acid; acetic acid; at 60 ℃; for 3h;

upstream raw materials:

2,3-dichloro-1,4-benzoquinone

3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

methyl (3,4,5-trimethoxyphenyl) ketone

Downstream raw materials:

6,7-dichloro-3-(3,4,5-trimethoxy-benzoyl)-benzofuran-4,5-dione

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