2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione

Base Information

• Chemical Name: 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione
• CAS No.: 204777-75-3
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 204777-75-3.mol

Synonyms:2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione

Chemical Property of 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione

There total 1 articles about 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) + dimedone (126-81-8) → 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione (204777-75-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide;

DOI:10.1016/S0040-4039(97)10828-0

Reference yield: 100.0%

ethylenediamine (107-15-3,85404-18-8) + 2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione (204777-75-3) → 2-{1-[(2-aminoethyl)amino]-2-phenylethylidene}-5,5-dimethyl-1,3-cyclohexanedione (623929-46-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 36h;

DOI:10.1021/jo0348874

Reference yield:

2-(1-hydroxy-2-phenylethylidene)-5,5-dimethylcyclohexane-1,3-dione (204777-75-3) → C27H41N4O4S(1+)*F6P(1-)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / TFA / CH₂Cl₂ / 36 h / 20 °C

2: 69 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

3: acetone / 18 h / 20 °C

4: ammonium hexafluorophosphate / CH₂Cl₂; methanol / 18 h / 20 °C

With ammonium hexafluorophosphate; trifluoroacetic acid; In methanol; dichloromethane; acetone;

DOI:10.1021/jo0348874

upstream raw materials:

phenylacetic acid

dimedone

Downstream raw materials:

2-{1-[(2-aminoethyl)amino]-2-phenylethylidene}-5,5-dimethyl-1,3-cyclohexanedione

[2-(3-{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethyl}thioureido)ethyl]carbamic acid tert-butyl ester

{2-[N'-{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethyl}-N''-(2,2,2-trifluoroacetyl)guanidino]ethyl}carbamic acid tert-butyl ester