2069-41-2Relevant articles and documents
AIBN initiated functionalization of the benzylic sp3 C[sbnd]H and C[sbnd]C bonds in the presence of dioxygen
Hu, Yingying,Shao, Yu,Zhang, Shuwei,Yuan, Yuan,Sun, Zheng,Yuan, Yu,Jia, Xiaodong
supporting information, (2021/02/01)
A sp3 C[sbnd]H bond functionalization and C[sbnd]C bond cleavage were realized by AIBN/O2 catalyst system, providing a series of benzophenones under mild reaction conditions. The mechanistic study shows that a peroxide intermediate is involved in this transformation, and in the case of diphenylmethanes, the sp3 C[sbnd]C bond is cleaved through the peroxide rearrangement, which might provides a new way to cleave relatively strong C[sbnd]C bond and be applied to more general C[sbnd]C bond activation.
Compounds and preparation methods and applications thereof
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Paragraph 0113-0118, (2022/01/05)
The present invention discloses a compound and a preparation method and application thereof. Compounds of the present invention may be used as thermal excitation delayed fluorescent materials for the preparation of organic electroluminescent devices.
Organic white light material with thermal activation delay and aggregation-induced emission performance and synthetic method and application thereof
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Paragraph 0062; 0063; 0064; 0065, (2016/10/09)
The invention provides an organic white light material with the terminal activation delay and aggregation-induced emission performance and a synthetic method and application thereof. The general molecular formula of the white light material is Ar-Ar1-Ar2, wherein Ar is a phenothiazine electron-donating substituent group, Ar1 is a strong electron-withdrawing group, and Ar2 is an aromatic fused ring or heterocyclic aromatic substituent group except phenothiazine. The synthetic method of the material is simple, the thermal performance, luminous efficiency and white light color purity of an end product can be adjusted through connection of different aromatic fused ring or heterocyclic aromatic groups, the white light material has the thermal activation delay and aggregation-induced emission properties, the glass transition temperature is high, and the emission performance is excellent. The obtained white light material is a light emitting layer applied to preparing a non-doped OLED device, the illumination brightness is high, the stability is good, and the practicability requirement can be met.
SUBSTITUTED PYRIMIDINES
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Page/Page column 67; 68, (2013/04/10)
Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
SUBSTITUTED PYRIMIDINES
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Page/Page column 67; 68, (2013/04/10)
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
LIQUID CRYSTAL OLIGOMER, SYNTHESIS COMPOSITION, PREPARATION METHOD THEREOF, AND LIQUID CRYSTAL MATERIAL
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Page/Page column 3, (2012/10/23)
The disclosed technology provides a liquid crystal oligomer, a synthesis composition, a preparation method thereof, and a liquid crystal material. The liquid crystal oligomer is represented by the following chemical formula, wherein substituent R is hydrogen or methyl. In addition to a higher glass transition temperature, good heat resistance, low viscosity and a self-crosslinkable group, the liquid crystal oligomer has thermal self-crosslinking and high thermal stability of thermosetting materials.
Synthesis of diaryl ketones via a phosphine-free Fukuyama reaction
Kunchithapatham, Kamala,Eichman, Chad C.,Stambuli, James P.
, p. 12679 - 12681 (2012/01/05)
The synthesis of unsymmetrical diaryl ketones via the Fukuyama coupling of thioesters and organozinc reagents is described. Typically, the synthesis of diaryl ketones using this methodology provides low yields. The simple complex, Pd(dba)2, was found to convert a variety of aryl thioesters to diaryl ketones in good yields. The Royal Society of Chemistry 2011.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
Kishore Kumar,Chavarria, Gustavo E.,Charlton-Sevcik, Amanda K.,Arispe, Wara M.,MacDonough, Matthew T.,Strecker, Tracy E.,Chen, Shen-En,Siim, Bronwyn G.,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.
supporting information; experimental part, p. 1415 - 1419 (2010/07/06)
A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis. The six most active inhibitors of cathepsin L (IC50 50 > 10,000 nM). The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.
IMIDAZOLYL-SUBSTITUTED BENZOPHENONE COMPOUNDS
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Page/Page column 35-36, (2008/06/13)
The compounds of formula (I) in which X, Y, R1 and R2 have the meanings as given in the description are novel effective inhibitors of the inducible nitric oxide synthase.
Preparation process of fluorine substituted aromatic compound
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, (2008/06/13)
A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.