3-NITRO-6-PYRIDINECARBOXALDEHYDE

Base Information

• Chemical Name: 3-NITRO-6-PYRIDINECARBOXALDEHYDE
• CAS No.: 35969-75-6
• Molecular Formula: C6H4 N2 O3
• Molecular Weight: 152.109
• Hs Code.: 2933399090
• Mol file: 35969-75-6.mol

Synonyms:Picolinaldehyde,5-nitro- (6CI); 5-Nitropyridine-2-carboxaldehyde

Chemical Property of 3-NITRO-6-PYRIDINECARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 54-57℃
• Refractive Index: 1.627
• Boiling Point: 298.7°Cat760mmHg
• PKA: -0.31±0.10(Predicted)
• Flash Point: 134.5°C
• PSA: 75.78000
• Density: 1.432g/cm³
• LogP: 1.32550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Nitropyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Nitropyridine-2-carbaldehyde is used in the synthetic preparation of pyridine-2-carboxaldehyde thiosemicarbazone which has antitumor activity.

Technology Process of 3-NITRO-6-PYRIDINECARBOXALDEHYDE

There total 9 articles about 3-NITRO-6-PYRIDINECARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-methyl-5-nitropyridine (21203-68-9) → 5-nitro-2-pyridinecarbaldehyde (35969-75-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 16h; Reflux;

Reference yield: 60.0%

5-nitro-pyridine-2-carboxylic acid methyl ester (29682-14-2) → 5-nitro-2-pyridinecarbaldehyde (35969-75-6)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

ethyl 5-nitropyridine-2-carboxylate (30563-98-5) → 5-nitro-2-pyridinecarbaldehyde (35969-75-6)

Guidance literature:

With diisobutylaluminium hydride; Rochelle's salt; In dichloromethane; water; at -78 - 20 ℃; Inert atmosphere;

upstream raw materials:

2-methyl-5-nitropyridine

2-chloro-5-nitropyridine

ethyl 5-nitropyridine-2-carboxylate

1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate

Downstream raw materials:

N-(5-nitropyridin-2-ylmethyl)-N-pyridin-2-ylmethylbenzamide

N-(5-aminopyridin-2-ylmethyl)-N-pyridin-2-ylmethylbenzamide

6-((4-methylpiperazin-1-yl)methyl)pyridin-3-amine

Refernces

• 1、 -. "AKT3 MODULATORS". Paragraph 0470. . Retrieved 2021/11/13.
• 2、 -. "METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS". Paragraph 0314; 0315. . Retrieved 2018/05/16.