7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

Base Information

Chemical Name:7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one
CAS No.:178375-65-0
Molecular Formula:C₂₇H₂₃F₂NO₄
Molecular Weight:463.481
Hs Code.:

Synonyms:7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

Suppliers and Price of 7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

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Chemical Property of 7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

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Technology Process of 7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

There total 6 articles about 7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17715-70-7
1,3-dimethoxy-4-fluorobenzene

: 178375-65-0
7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 48percent HBr, AcOH / 16 h

2: 1.) triflic acid, 2.) 2 N aq. NaOH / 1.) 80 deg C, 4 h, 2.) RT, 16 h

3: K₂CO₃ / acetone / 6 h / Heating

4: Br₂ / ethyl acetate / 2 h

5: Et₃N / acetonitrile / 16 h

With sodium hydroxide; trifluorormethanesulfonic acid; hydrogen bromide; bromine; potassium carbonate; acetic acid; triethylamine; In ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm9707986

Reference yield:

: 103068-41-3
4-fluororesorcinol

: 178375-65-0
7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triflic acid, 2.) 2 N aq. NaOH / 1.) 80 deg C, 4 h, 2.) RT, 16 h

2: K₂CO₃ / acetone / 6 h / Heating

3: Br₂ / ethyl acetate / 2 h

4: Et₃N / acetonitrile / 16 h

With sodium hydroxide; trifluorormethanesulfonic acid; bromine; potassium carbonate; triethylamine; In ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm9707986

Reference yield:

: 178374-98-6
6-fluoro-7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 178375-65-0
7-benzyloxy-6-fluoro-3-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-chromen-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 6 h / Heating

2: Br₂ / ethyl acetate / 2 h

3: Et₃N / acetonitrile / 16 h

With bromine; potassium carbonate; triethylamine; In ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm9707986