methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Base Information

Chemical Name:methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate
CAS No.:251996-63-1
Molecular Formula:C₁₈H₁₃NO₅S
Molecular Weight:355.371
Hs Code.:

Synonyms:methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Suppliers and Price of methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

There total 5 articles about methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 251996-62-0
methyl 4-{4-[(E)-3-(tert-butyloxy)-3-oxo-1-propenyl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

: 251996-63-1
methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 4h;
DOI:10.1021/jm0101702

Reference yield:

: 106-41-2
4-bromo-phenol

: 251996-63-1
methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 25 °C

1.2: tetrahydrofuran / 2 h / 70 °C

2.1: Cs₂CO₃ / tetrahydrofuran / 0.5 h / 70 °C

3.1: 57 percent / tri-o-tolylphosphine; triethylamine / Pd₂(dba)3 / dimethylformamide / 12 h / 100 °C

4.1: 100 percent / trifluoroacetic acid / CHCl₃ / 4 h / 20 °C

With potassium tert-butylate; caesium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.1021/jm0101702

Reference yield:

: 136590-83-5
3,5-dichloropyridine-4-carboxaldehyde

: 251996-63-1
methyl 4-{4-[(E)-propenoic acid-1-yl]phenoxy}thieno[2,3-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 25 °C

1.2: tetrahydrofuran / 2 h / 70 °C

2.1: Cs₂CO₃ / tetrahydrofuran / 0.5 h / 70 °C

3.1: 57 percent / tri-o-tolylphosphine; triethylamine / Pd₂(dba)3 / dimethylformamide / 12 h / 100 °C

4.1: 100 percent / trifluoroacetic acid / CHCl₃ / 4 h / 20 °C

With potassium tert-butylate; caesium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.1021/jm0101702