(1R,2S,3R,4S)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Base Information

Chemical Name:(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide
CAS No.:106644-77-3
Molecular Formula:C₂₈H₃₅N₅O₃
Molecular Weight:489.618
Hs Code.:

Synonyms:(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

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Chemical Property of (1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

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Technology Process of (1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

There total 6 articles about (1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 87789-61-5
1-(5-Benzyloxy-2-pyrimidinyl)piperazine

: 99095-09-7
(1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide

: 106644-77-3
(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1248/cpb.39.2288

Reference yield:

: 2746-19-2
(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

: 106644-77-3
(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Guidance literature:: Multi-step reaction with 4 steps

1: 95.9 percent / H₂ / 10percent Pd-C/ 50percent H₂O / tetrahydrofuran / 1.5 h / Ambient temperature

2: 80.5 percent / 7percent aq. NH₃ / tetrahydrofuran / 2 h / 190 °C

3: 90.2 percent / K₂CO₃ / acetone / 7 h / Heating

4: 88.9 percent / K₂CO₃, KI / dimethylformamide / 90 °C

With ammonium hydroxide; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; water; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.39.2288

Reference yield:

: 100-39-0
benzyl bromide

: 106644-77-3
(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Guidance literature:: Multi-step reaction with 3 steps

1: 89.7 percent / K₂CO₃ / dimethylformamide / 1 h / 90 - 100 °C

2: 50.6 percent / ethanol / 1.) ice bath, 2.) room temperature

3: 88.9 percent / K₂CO₃, KI / dimethylformamide / 90 °C

With potassium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2288