6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

Base Information

• Chemical Name: 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid
• CAS No.: 1309959-27-0
• Molecular Formula: C₁₇H₁₁Cl₂F₃N₂O₃
• Molecular Weight: 419.187
• Mol file: 1309959-27-0.mol

Synonyms:6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

Chemical Property of 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

There total 6 articles about 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H19Cl2F3N2O3 (1309959-28-1) → 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid (1309959-27-0)

Guidance literature:

C₂₁H₁₉Cl₂F₃N₂O₃; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

5-bromo-4-methylpyridine-2-carbaldehyde (886364-94-9) → 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid (1309959-27-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: palladium diacetate; 1,4-diaminobutane; catacxium A / butan-1-ol / 0.33 h / 20 °C / 11251.1 Torr

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; sodium hydroxide; palladium diacetate; 1,4-diaminobutane; catacxium A; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

5-bromo-2-iodo-4-methylpyridine (941294-57-1) → 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid (1309959-27-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / -15 - -10 °C

1.2: 1 h / -15 - 0 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: palladium diacetate; 1,4-diaminobutane; catacxium A / butan-1-ol / 0.33 h / 20 °C / 11251.1 Torr

5.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; isopropylmagnesium bromide; sodium acetate; sodium hydroxide; palladium diacetate; 1,4-diaminobutane; catacxium A; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

2,5-Dibromo-4-methylpyridine

5-bromo-4-methylpyridine-2-carbaldehyde

5-bromo-2-iodo-4-methylpyridine

5-bromo-4-methyl-pyridine-2-carbaldehyde oxime