5-Bromo-2-iodo-4-picoline

Base Information

• Chemical Name: 5-Bromo-2-iodo-4-picoline
• CAS No.: 941294-57-1
• Molecular Formula: C₆H₅BrIN
• Molecular Weight: 297.921
• Hs Code.: 2933399090
• Mol file: 941294-57-1.mol

Synonyms:5-Bromo-2-iodo-4-methylpyridine

Chemical Property of 5-Bromo-2-iodo-4-picoline

Chemical Property:

• Boiling Point: 282.6±35.0 °C(Predicted)
• PKA: 0.14±0.18(Predicted)
• PSA: 12.89000
• Density: 2.171±0.06 g/cm3(Predicted)
• LogP: 2.75710
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

5-Bromo-2-iodo-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-iodo-4-picoline

There total 1 articles about 5-Bromo-2-iodo-4-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-Dibromo-4-methylpyridine (3430-26-0) → 5-bromo-2-iodo-4-methylpyridine (941294-57-1)

Guidance literature:

2,5-Dibromo-4-methylpyridine; With acetyl chloride; sodium iodide; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

5-bromo-2-iodo-4-methylpyridine (941294-57-1) → C21H19Cl2F3N2O3 (1309959-28-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / -15 - -10 °C

1.2: 1 h / -15 - 0 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: palladium diacetate; 1,4-diaminobutane; catacxium A / butan-1-ol / 0.33 h / 20 °C / 11251.1 Torr

With N-chloro-succinimide; hydroxylamine hydrochloride; isopropylmagnesium bromide; sodium acetate; palladium diacetate; 1,4-diaminobutane; catacxium A; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

5-bromo-2-iodo-4-methylpyridine (941294-57-1) → 6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid (1309959-27-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / -15 - -10 °C

1.2: 1 h / -15 - 0 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: palladium diacetate; 1,4-diaminobutane; catacxium A / butan-1-ol / 0.33 h / 20 °C / 11251.1 Torr

5.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; isopropylmagnesium bromide; sodium acetate; sodium hydroxide; palladium diacetate; 1,4-diaminobutane; catacxium A; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

2,5-Dibromo-4-methylpyridine

Downstream raw materials:

5-bromo-4-methylpyridine-2-carbaldehyde

5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine

C₂₁H₁₉Cl₂F₃N₂O₃

6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

Refernces

• 1、 -. "INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES". Page/Page column 36. . Retrieved 2012/09/25.