N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide
• CAS No.: 357436-82-9
• Molecular Formula: C₂₆H₂₆N₄O₄
• Molecular Weight: 458.517

Synonyms:N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide

Chemical Property of N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide

Chemical Property:

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Technology Process of N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide

There total 3 articles about N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-methyl-piperazine (109-01-3) + N-(2-benzoyl-4-nitrophenyl)-2-chloro-2-phenylacetamide (357436-81-8) → N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide (357436-82-9)

Guidance literature:

In acetonitrile; Reflux;

DOI:10.1016/j.bmc.2009.09.043

Reference yield:

α-chlorophenylacetyl chloride (2912-62-1) → N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide (357436-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: acetonitrile / 24 h / Heating

In 1,4-dioxane; toluene; acetonitrile;

DOI:10.1002/anie.200351169

Reference yield:

2-amino-5-nitrobenzophenone (1775-95-7) → N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide (357436-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: acetonitrile / 24 h / Heating

In 1,4-dioxane; toluene; acetonitrile;

DOI:10.1002/anie.200351169

upstream raw materials:

1-methyl-piperazine

N-(2-benzoyl-4-nitrophenyl)-2-chloro-2-phenylacetamide

α-chlorophenylacetyl chloride

2-amino-5-nitrobenzophenone

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