ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate

Base Information

• Chemical Name: ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate
• CAS No.: 1293993-84-6
• Molecular Formula: C₁₈H₁₈N₂O₃
• Molecular Weight: 310.353
• Mol file: 1293993-84-6.mol

Synonyms:ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate

Chemical Property of ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate

There total 7 articles about ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3-amino-4-(2-hydroxyethylamino)benzoate (91430-70-5) + sodium hydroxy(phenyl)methanesulfonate (4657-12-9) → ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate (1293993-84-6)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.12.029

Reference yield: 85.0%

ethyl 3-amino-4-(2-hydroxyethylamino)benzoate (91430-70-5) + benzaldehyde (100-52-7) → ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate (1293993-84-6)

Guidance literature:

With sodium hydrogen sulfate; In water; at 20 ℃; Green chemistry;

DOI:10.2174/157017861110141117150010

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate (1293993-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 8 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: 10% Pd/C; ammonium formate / ethanol / 0.03 h / 100 °C / Microwave irradiation

4: N,N-dimethyl-formamide / 0.05 h / 130 °C / Microwave irradiation

With sulfuric acid; 10% Pd/C; ammonium formate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules17089887

upstream raw materials:

benzaldehyde

ethyl 3-amino-4-(2-hydroxyethylamino)benzoate

sodium hydroxy(phenyl)methanesulfonate

3-nitro-4-fluorobenzoic acid

Downstream raw materials:

C₅₂H₅₂N₂O₈

C₂₄H₂₈N₂O₈