N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

Base Information

Chemical Name:N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine
CAS No.:1036754-00-3
Molecular Formula:C₂₄H₂₅N₅O₂S
Molecular Weight:447.561
Hs Code.:

Synonyms:N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

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Chemical Property of N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

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Technology Process of N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

There total 12 articles about N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1036753-86-2
N-(3-methoxyphenyl)-7-(piperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

: 1036754-00-3
N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

Guidance literature:: formaldehyd; N-(3-methoxyphenyl)-7-(piperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine; With acetic acid; In methanol; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 1h;

Reference yield:

: C₂₄H₂₃N₅O₂S

: 1036754-00-3
N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

Guidance literature:: C₂₄H₂₃N₅O₂S; With sodium triacetoxy borohydride; In methanol; at 20 ℃; for 1h;

With methanol;

Reference yield:

: 953040-63-6
6-bromo-2-chloro-7-methoxyquinazoline

: 1036754-00-3
N-(3-methoxyphenyl)-7-(1-methylpiperidin-4-yloxy)-6-(thiazol-2-yl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2.1: hydrogenchloride; water / pH 5.5

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere of nitrogen

3.2: 20 °C

4.1: Oxone / tetrahydrofuran; water / 0 - 20 °C

5.1: 1,4-dioxane / 24 h / 110 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.17 h / 120 °C / Irradiation with microwave

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

8.1: acetic acid / methanol / 0.17 h / 20 °C

9.1: sodium triacetoxy borohydride / methanol / 1 h / 20 °C

With sodium triacetoxy borohydride; hydrogenchloride; Oxone; water; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;