5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one

Base Information

• Chemical Name: 5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one
• CAS No.: 959979-04-5
• Molecular Formula: C₂₀H₂₀N₂O₂
• Molecular Weight: 320.391
• Mol file: 959979-04-5.mol

Synonyms:5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one

Chemical Property of 5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one

There total 1 articles about 5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione (59048-75-8) + phenyllithium (591-51-5) → 5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one (959979-04-5)

Guidance literature:

In tetrahydrofuran; dibutyl ether; at -78 ℃; for 2h;

DOI:10.1021/ja076179w

Reference yield:

5-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-phenylpyrrolidin-2-one (959979-04-5) → (11bS)-11b-phenyl-1,2,5,6,11,11b-hexahydro-3H-indolizino[8,7-b]indol-3-one (959979-05-6) + (11bR)-11b-phenyl-1,2,5,6,11,11b-hexahydro-3H-indolizino[8,7-b]indol-3-one

Guidance literature:

With chloro-trimethyl-silane; R,R-derivative of cyclohexyl-carbamothioyl-L-valinamide; In various solvent(s); at -78 ℃; for 48h; Title compound not separated from byproducts.;

DOI:10.1021/ja076179w

upstream raw materials:

N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

phenyllithium

Downstream raw materials:

(11bS)-11b-phenyl-1,2,5,6,11,11b-hexahydro-3H-indolizino[8,7-b]indol-3-one