1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

Base Information

Chemical Name:1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione
CAS No.:59048-75-8
Molecular Formula:C14H14N2O2
Molecular Weight:242.277
Hs Code.:
DSSTox Substance ID:DTXSID70354986
Nikkaji Number:J1.958.100D
Wikidata:Q82133532
ChEMBL ID:CHEMBL1904703

Synonyms:1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione;59048-75-8;1-(2-(1H-Indol-3-yl)ethyl)pyrrolidine-2,5-dione;Oprea1_504051;Oprea1_685882;MLS000554274;SCHEMBL733677;CHEMBL1904703;DTXSID70354986;HYENFSOYXDDPGQ-UHFFFAOYSA-N;HMS2287F10;STK047285;AKOS005384871;SMR000146591;1-[2-(1H-Indol-3-yl)-ethyl]-pyrrolidine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:242.105527694
Heavy Atom Count:18
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)N(C1=O)CCC2=CNC3=CC=CC=C32

Technology Process of 1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

There total 1 articles about 1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 108-30-5
succinic acid anhydride

: 61-54-1
tryptamine

: 59048-75-8
N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

: 92870-51-4
N'-<3-(methoxycarbonyl)propanoyl>tryptamine

Guidance literature:: succinic acid anhydride; tryptamine; In tetrahydrofuran; at 20 ℃; for 0.333333h;

diazomethane; In methanol; diethyl ether; at 20 ℃; for 0.0833333h;
DOI:10.1248/cpb.49.87

Reference yield: 84.0%

: 59048-75-8
N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

: 32283-51-5
1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one

Guidance literature:: N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione; With boron tribromide; In dichloromethane; at 20 ℃; for 12h; Molecular sieve; Inert atmosphere;

With sodium tetrahydroborate; In methanol; dichloromethane; for 0.5h; Molecular sieve; Inert atmosphere;
DOI:10.1007/s12039-015-0836-8

Reference yield: 57.0%

: 59048-75-8
N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 1004546-82-0
1-(2-(2-(4-(Dimethylamino)-4-phenylcyclohex-1-enyl)-1H-indol-3-yl)ethyl)pyrrolidine-2.5-dione

Guidance literature:: N-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,5-dione; 4-dimethylamino-4-phenylcyclohexanone; With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In dichloromethane;