methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Base Information

Chemical Name:methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester
CAS No.:423763-86-4
Molecular Formula:C₂₆H₄₇NO₆SSi
Molecular Weight:529.814
Hs Code.:

methanesulfonic acid 5-(<i>tert</i>-butoxycarbonyl-methyl-amino)-7-(<i>tert</i>-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Synonyms:methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Suppliers and Price of methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

There total 13 articles about methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-63-0
methanesulfonyl chloride

: 423763-85-3
{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

: 423763-86-4
methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 6249-80-5
1-phenylbut-3-en-1-one

: 423763-86-4
methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 84 percent / (+)-Ipc₂BCl / tetrahydrofuran / 12 h / -35 °C

2.1: 90 percent / n-BuLi / diethyl ether; tetrahydrofuran / 2.5 h / -78 - 20 °C

3.1: 85 percent / IBr / toluene; CH₂Cl₂ / 1 h / -85 °C

4.1: 96 percent / K₂CO₃ / methanol / 2 h / 20 °C

5.1: 96 percent / Et₃N; DMAP / dimethylformamide / 3 h / 20 °C

6.1: 91 percent / CuI / diethyl ether / 0.5 h / -40 °C

7.1: 88 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

8.1: 83 percent / dimethylformamide; H₂O / 20 h / 60 °C

9.1: 95 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

10.1: Cy₂BH / CH₂Cl₂ / 6 h / 0 - 20 °C

10.2: 90 percent / H₂O₂; NaOH / H₂O / 1 h / 0 - 20 °C

11.1: 95 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

With dmap; copper(l) iodide; n-butyllithium; (+)-β-chlorodiisopinocampheylborane; bis(cyclohexanyl)borane; iodine(I) bromide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 423763-86-4
methanesulfonic acid 5-(tert-butoxycarbonyl-methyl-amino)-7-(tert-butyl-dimethyl-silanyloxy)-7-phenyl-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

2.1: Cy₂BH / CH₂Cl₂ / 6 h / 0 - 20 °C

2.2: 90 percent / H₂O₂; NaOH / H₂O / 1 h / 0 - 20 °C

3.1: 95 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

With bis(cyclohexanyl)borane; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(01)02105-0