(3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

Base Information

• Chemical Name: (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one
• CAS No.: 1312443-47-2
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46

Synonyms:(3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

Chemical Property of (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

Chemical Property:

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Technology Process of (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

There total 3 articles about (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + N,N'-(((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(1-phenylmethanamine) (679399-14-5) → (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one (1312443-47-2)

Guidance literature:

With pyridine; tungsten hexacarbonyl; iodine; In dichloromethane; at 40 ℃; for 24h; under 60006 Torr; Autoclave;

DOI:10.1016/j.tet.2011.04.015

Reference yield:

benzylamine (100-46-9) → (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one (1312443-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / 1,4-dioxane / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: pyridine; tungsten hexacarbonyl; iodine / dichloromethane / 24 h / 40 °C / 60006 Torr / Autoclave

With pyridine; lithium aluminium tetrahydride; tungsten hexacarbonyl; iodine; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1016/j.tet.2011.04.015

Reference yield:

(-)-dimethy-2,3-O-isopropylidene-L-tartrate (37031-29-1) → (3aS,8aS)-5,7-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one (1312443-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / 1,4-dioxane / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: pyridine; tungsten hexacarbonyl; iodine / dichloromethane / 24 h / 40 °C / 60006 Torr / Autoclave

With pyridine; lithium aluminium tetrahydride; tungsten hexacarbonyl; iodine; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1016/j.tet.2011.04.015

upstream raw materials:

(-)-dimethy-2,3-O-isopropylidene-L-tartrate

carbon monoxide

N,N'-(((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(1-phenylmethanamine)

benzylamine

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