5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

Base Information

• Chemical Name: 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone
• CAS No.: 409346-50-5
• Molecular Formula: C₂₇H₃₃NO₃S
• Molecular Weight: 451.63
• Mol file: 409346-50-5.mol

Synonyms:5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

Chemical Property of 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

There total 1 articles about 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

sodium methylate (124-41-4) + 2-(Pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone (409345-01-3) → 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone (409346-50-5) + 5-Methoxy-3-(pyridin-2-ylsulfanyl)-2-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

Guidance literature:

In tetrahydrofuran; methanol; at -20 ℃; for 1h;

DOI:10.1021/ja027517q

Reference yield: 82.0%

sodium methylate (124-41-4) + 5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone (409346-50-5) → [1R-(1α,2β,4aβ,8aα)]-3-[(decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl)methyl]-2,5-dimethoxy-2,5-cyclohexadiene-1,4-dione (121994-56-7)

Guidance literature:

In methanol; at -20 - 50 ℃;

DOI:10.1021/ja027517q

Reference yield:

5-Methoxy-2-(pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone (409346-50-5) → ilimaquinone (71678-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / methanol / -20 - 50 °C

2: 78 percent / aq. HClO₄ / tetrahydrofuran / 4 h / 25 °C

With perchloric acid; In tetrahydrofuran; methanol;

DOI:10.1021/ja027517q

upstream raw materials:

sodium methylate

2-(Pyridin-2-ylsulfanyl)-3-((1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone

Downstream raw materials:

[1R-(1α,2β,4aβ,8aα)]-3-[(decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl)methyl]-2,5-dimethoxy-2,5-cyclohexadiene-1,4-dione

ilimaquinone

smenospongiadine