1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane

Base Information

• Chemical Name: 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane
• CAS No.: 66255-13-8
• Molecular Formula: C₁₃H₂₆OSi
• Molecular Weight: 226.434
• Mol file: 66255-13-8.mol

Synonyms:1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane

Chemical Property of 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane

There total 8 articles about 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(1,1-dimethylethyl)cyclohexen-1-yltrimethylsilane (63031-67-4) → 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane (66255-13-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1021/ja00259a036

Reference yield:

4-(1,1-dimethylethyl)cyclohexen-1-yltrimethylsilane (63031-67-4) → 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane (66255-13-8) + 5-(1,1-dimethylethyl)-2-trimethylsilyl-2-cyclohexen-1-one

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/00404-0399(50)0960K-

Reference yield:

1-chloro-4-tert-butylcyclohexene (6832-09-3) → 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane (66255-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Na / diethyl ether

2: 85 percent / 83percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 12 h / 0 °C

With sodium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00259a036

upstream raw materials:

4-(1,1-dimethylethyl)cyclohexen-1-yltrimethylsilane

1-chloro-4-tert-butylcyclohexene

4-tercbutyl-cyclohexanone

Downstream raw materials:

4-(2-methylpropyl)-1e-(trimethylsilyl)cyclohexanol

4-(2-methylpropyl)-1a-(trimethylsilyl)cyclohexanol

cis-1-(trimethylsilyl)-trans-4-tert-butylcyclohexan-2-ol

cis-1-(trimethylsilyl)-cis-4-tert-butylcyclohexan-2-ol