63031-67-4

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 41780-53-4 4-tert-butylcyclohexanone tosylhydrazone 
• 66227-83-6 (+/-)-4-tert.Butylcyclohexanon-benzolsulfonylhydrazon 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 6832-09-3 1-chloro-4-tert-butylcyclohexene 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 7370-14-1 4-tert-butyl-1-cyanocyclohexene 
• 71624-75-4 (4-tert-Butyl-cyclohex-1-enylsulfanyl)-benzene 

Downstream Products

• 66255-13-8 1-(trimethylsilyl)-4-tert-butyl-7-oxa-cis-bicyclo<4.1.0>heptane 
• 71352-20-0 trans-2-(trimethylsilyl)-5-tert-butylcyclohex-2-en-1-ol 
• 71352-19-7 cis-2-(trimethylsilyl)-5-tert-butylcyclohex-2-en-1-ol 
• 66227-98-3 c-4-t-butyl-r-1-trimethylsilyl-7-oxabicyclo<4.1.0>heptane 
• 66227-98-3 t-4-t-butyl-r-1-trimethylsilyl-7-oxabicyclo<4.1.0>heptane 
• 73872-59-0 C₁₃H₂₇⁽²⁾HOSi 
• 73872-59-0 C₁₃H₂₇⁽²⁾HOSi 
• 73872-67-0 1-(trimethylsilyl)-2-deuterio-4-tert-butylcyclohexanol 
• 73872-60-3 4-tert-butyl-1-deuteriocyclohexene 
• 119061-94-8 2-(4-tert-Butyl-cyclohex-1-enyl)-2-hexyl-indan-1,3-dione 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 119547-64-7 t-5-t-butyl-r-3-methoxy-2-trimethylsilylcyclohexene 
• 75415-89-3 4-tert-Butyl-1-nitro-cyclohexene 
• 23525-05-5 1-bromo-4-(tert-butyl)cyclohex-1-ene 

Relevant academic research and scientific papers

Sodium silylsilanolate enables nickel-catalysed silylation of aryl chlorides

Structurally diverse aryl chlorides were silylated with sodium silylsilanolate reagents in the presence of a Ni(cod)2catalyst complexed with a phosphine ligand; PMe2Ph for electron-rich substrates, and PCy2Ph for electron-deficient ones. The mild reaction conditions allowed the silylation of various aryl chlorides including functionalised drug molecules.

Synthesis of Ketones and Esters from Heteroatom-Functionalized Alkenes by Cobalt-Mediated Hydrogen Atom Transfer

Cobalt bis(acetylacetonate) is shown to mediate hydrogen atom transfer to a broad range of functionalized alkenes; in situ oxidation of the resulting alkylradical intermediates, followed by hydrolysis, provides expedient access to ketones and esters. By modification of the alcohol solvent, different alkyl ester products may be obtained. The method is compatible with a number of functional groups including alkenyl halides, sulfides, triflates, and phosphonates and provides a mild and practical alternative to the Tamao-Fleming oxidation of vinylsilanes and the Arndt-Eistert homologation.

Rhodium-catalyzed silylation and intramolecular arylation of nitriles via the silicon-assisted cleavage of carbon-cyano bonds

A rhodium-catalyzed silylation reaction of carbon - cyano bonds using disilane has been developed. Under these catalytic conditions, carbon-cyano bonds in aryl, alkenyl, allyl, and benzyl cyanides bearing a variety of functional groups can be silylated. The observation of an enamine side product in the silylation of benzyl cyanides and related stoichiometric studies indicate that the carbon-cyano bond cleavage proceeds through the deinsertion of silyl isocyanide from η2-iminoacyl complex B. Knowledge gained from these studies has led to the development of a new intramolecular biaryl coupling reaction in which aryl cyanides and aryl chlorides are cross-coupled.

Rh(I)-catalyzed silylation of aryl and alkenyl cyanides involving the cleavage of C-C and Si-Si bonds

The Rh(I)-catalyzed silylation of nitriles with disilanes is described. The cleavage of inert carbon-cyano and silicon-silicon bonds occurs in this catalysis. Copyright

One-pot synthesis of α-trimethylsilyl enones from vinylsilanes

Photooxygenation of vinylsilanes in the presence of acetic anhydride and pyridine afforded α-trimethylsilyl enones 1 in moderate to good yields. Since the required starting materials are readily available, the present approach constitutes a useful alterna

A Simple Method for Producing Cycloalkenyllithiums from Cycloalkanones via Reductive Lithiation of Enol Phenyl Thioethers

Cyclohexenyl, cycloheptenyl, and cyclooctenyl phenyl sulfides, readily prepared from the corresponding cycloalkanones, are reductively lithiated by lithium p,p'-di-tert-butylbiphenylide to produce cycloalkenyllithiums in good yields.

Silanes in Organic Synthesis. 8. Preparation of Vinylsilanes from Ketones and Their Regiospecific Cyclopentenone Annulation

A general method is described for the formation of vinylsilanes from ketones.Thus, conversion to the benzene- or p-toluenesulfonylhydrazone and sequential treatment with n-butyllithium and chlorotrimethylsilane in anhydrous tetramethylethylenediamine proceeds regiospecifically to afford the less substituted vinylsilane (in unsymmetrical cases).Friedel-Crafts acylation with acryloyl chlorides and aluminium chloride and subsequent Nazarov cyclization with Lewis acid catalysis results in cyclopentenone annulation.Numerous examples that reveal the scope of this processare described.Due to accompanying polymerization, annulation with acryloyl chloride itself is least efficient.This complication can, however, be averted through use of β-chloropropionyl chloride and dehydrochlorination with 1,5-diazabicycloundec-5-ene prior to ring closure.