dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate

Base Information

• Chemical Name: dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate
• CAS No.: 184775-17-5
• Molecular Formula: C₃₃H₃₂F₆N₂O₆
• Molecular Weight: 666.617
• Mol file: 184775-17-5.mol

Synonyms:dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate

Chemical Property of dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate

There total 10 articles about dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Methyl-3-(2,2,2-trifluoro-1-methoxy-ethyl)-1H-pyrrole-2-carboxylic acid benzyl ester (184775-15-3) + 5-Acetoxymethyl-3-methyl-4-(2,2,2-trifluoro-1-methoxy-ethyl)-1H-pyrrole-2-carboxylic acid benzyl ester (184775-16-4) → dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate (184775-17-5)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/0040-4020(96)00858-7

Reference yield:

benzyl 3,5-dimethylpyrrole-2-carboxylate (40236-19-9) → dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate (184775-17-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / ZnCl₂

2: 78 percent / NaH / tetrahydrofuran

3: 93 percent / acetic acid

4: 90 percent / BF₃*OEt₂ / CH₂Cl₂

With boron trifluoride diethyl etherate; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane; acetic acid;

Reference yield:

benzyl 4-(1-hydroxy-2,2,2-trifluoroethyl)-3,5-dimethylpyrrole-2-carboxylate (184775-08-4) → dibenzyl 3,4'-bis(2,2,2-trifluoro-1-methoxyethyl)-4,3'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate (184775-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / NaH / tetrahydrofuran

2: 93 percent / acetic acid

3: 90 percent / BF₃*OEt₂ / CH₂Cl₂

With boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; dichloromethane; acetic acid;

upstream raw materials:

4-Methyl-3-(2,2,2-trifluoro-1-methoxy-ethyl)-1H-pyrrole-2-carboxylic acid benzyl ester

5-Acetoxymethyl-3-methyl-4-(2,2,2-trifluoro-1-methoxy-ethyl)-1H-pyrrole-2-carboxylic acid benzyl ester

benzyl 3,5-dimethylpyrrole-2-carboxylate

4-Methyl-3-(2,2,2-trifluoro-1-methoxy-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester