Alprostadil ethyl ester

Base Information

Chemical Name:Alprostadil ethyl ester
CAS No.:35900-16-4
Molecular Formula:C₂₂H₃₈O₅
Molecular Weight:382.541
Hs Code.:
European Community (EC) Number:806-708-3
UNII:IG6WR57RZT
DSSTox Substance ID:DTXSID10189476
Nikkaji Number:J562.382K
Wikidata:Q27280712
Mol file:35900-16-4.mol

Synonyms:PGE1 ethyl ester;prostaglandin E1 ethyl ester

Suppliers and Price of Alprostadil ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Prostaglandin E1 ethyl ester ≥95%
1mg
$ 175.00

Cayman Chemical
Prostaglandin E1 ethyl ester ≥95%
500μg
$ 94.00

Cayman Chemical
Prostaglandin E1 ethyl ester
100μg
$ 25.00

Cayman Chemical
Prostaglandin E1 ethyl ester ≥95%
5mg
$ 563.00

AK Scientific
Alprostadilethylester
1mg
$ 336.00

Total 7 raw suppliers

Chemical Property of Alprostadil ethyl ester

Chemical Property:

PSA：83.83000
LogP:3.95360
Storage Temp.:−20°C
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:15
Exact Mass:382.27192431
Heavy Atom Count:27
Complexity:460

Purity/Quality:

95% ^*data from raw suppliers

Prostaglandin E1 ethyl ester ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F,Xn,Xi
Statements: 11-20/21/22-36/37/38-67-66-36
Safety Statements: 16-26-36/37/39-33-29

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)OCC)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)OCC)O)O

Technology Process of Alprostadil ethyl ester

There total 10 articles about Alprostadil ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.8%

: 74-96-4
ethyl bromide

: 745-65-3
ALPROSTADIL

: 35900-16-4
ethyl 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoate

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 32556-71-1,37911-28-7
1-octyn-3-ol

: 22469-24-5,35900-16-4,55253-43-5
7-[(2S,3S)-3-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (i) (iBu)3Al, DIBAH, heptane, (ii) I₂, THF

2: aq. HCl

3: (i) Li, Et₂O, (ii) (nBu)3P*CuI, (iii) /BRN= 1435951/

With hydrogenchloride;
DOI:10.1021/ja00837a028

Reference yield:

: 32556-71-1,37911-28-7
1-octyn-3-ol

: 35900-16-4
ethyl 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: (i) (iBu)3Al, DIBAH, heptane, (ii) I₂, THF

2: aq. HCl

3: (i) Li, Et₂O, (ii) (nBu)3P*CuI, (iii) /BRN= 1435951/

With hydrogenchloride;
DOI:10.1021/ja00837a028