(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Base Information

Chemical Name:(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid
CAS No.:1265629-90-0
Molecular Formula:C₂₇H₂₃FN₂O₅
Molecular Weight:474.488
Hs Code.:

Synonyms:(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

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Chemical Property of (4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Chemical Property:

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Technology Process of (4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

There total 3 articles about (4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₇FN₂O₅

: 1265629-90-0
(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Guidance literature:: C₂₉H₂₇FN₂O₅; With water; lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃;

Acidic conditions;

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1265629-90-0
(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0.83 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

3.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

4.1: water; lithium hydroxide / 1,2-dimethoxyethane / 20 °C

4.2: Acidic conditions

With dimethylsulfide borane complex; diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; lithium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; 2.1: Curtius Rearrangement / 3.1: Suzuki Coupling;

Reference yield:

: 162427-79-4
(R)-1-(2-fluorophenyl)ethanol

: 1265629-90-0
(4'-{4-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

3.1: water; lithium hydroxide / 1,2-dimethoxyethane / 20 °C

3.2: Acidic conditions

With diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; toluene; 1.1: Curtius Rearrangement / 2.1: Suzuki Coupling;