(E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

Base Information

• Chemical Name: (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate
• CAS No.: 1430115-39-1
• Molecular Formula: C₁₁H₈ClFN₄O₂
• Molecular Weight: 282.662
• Mol file: 1430115-39-1.mol

Synonyms:(E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

Chemical Property of (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

There total 3 articles about (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chloro-5-fluoro-2-iodophenyl)-1H-tetrazole (1430115-38-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate (1430115-39-1)

Guidance literature:

With palladium diacetate; triethylamine; In acetonitrile; at 85 ℃; for 18h; Inert atmosphere;

Reference yield:

4-chloro-5-fluoro-2-iodo-phenylamine (1094759-93-9) → (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate (1430115-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; acetic acid / 30 h

2: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

With sodium azide; palladium diacetate; acetic acid; triethylamine; In acetonitrile;

Reference yield:

4-chloro-3-fluoroaniline (367-22-6) → (E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate (1430115-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; iodine / water / 0 - 20 °C

2: sodium azide; acetic acid / 30 h

3: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

With sodium azide; iodine; palladium diacetate; sodium hydrogencarbonate; acetic acid; triethylamine; In water; acetonitrile;

upstream raw materials:

4-chloro-5-fluoro-2-iodo-phenylamine

4-chloro-3-fluoroaniline

1-(4-chloro-5-fluoro-2-iodophenyl)-1H-tetrazole

acrylic acid methyl ester

Downstream raw materials:

(E)-3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylic acid

C₃₈H₃₃ClFN₉O₃

C₃₇H₃₃ClF₂N₈O₃

C₃₉H₃₇ClFN₉O₅