4-chloro-5-fluoro-2-iodoaniline

Base Information

• Chemical Name: 4-chloro-5-fluoro-2-iodoaniline
• CAS No.: 1094759-93-9
• Molecular Formula: C6H4ClFIN
• Molecular Weight: 271.46
• Mol file: 1094759-93-9.mol

Synonyms:4-chloro-5-fluoro-2-iodoaniline;4-Chloro-5-fluoro-2-iodo-phenylamine

Chemical Property of 4-chloro-5-fluoro-2-iodoaniline

Chemical Property:

• Boiling Point: 293.8±40.0 °C(Predicted)
• PKA: 0.88±0.10(Predicted)
• PSA: 26.02000
• Density: 2.089±0.06 g/cm3(Predicted)
• LogP: 3.24710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-5-fluoro-2-iodoaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-5-fluoro-2-iodoaniline

There total 2 articles about 4-chloro-5-fluoro-2-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-3-fluoroaniline (367-22-6) → 4-chloro-5-fluoro-2-iodo-phenylamine (1094759-93-9)

Guidance literature:

With iodine; calcium carbonate;

DOI:10.1021/op1001808

Reference yield:

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate (869299-68-3) → 4-chloro-5-fluoro-2-iodo-phenylamine (1094759-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Iodine monochloride; acetic acid

2: iodine; calcium carbonate

With iodine; Iodine monochloride; acetic acid; calcium carbonate;

DOI:10.1021/op1001808

Reference yield: 95.0%

methanol (67-56-1) + 4-chloro-5-fluoro-2-iodo-phenylamine (1094759-93-9) + carbon monoxide (201230-82-2) → C8H7ClFNO2 (936540-27-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 2585.81 Torr;

upstream raw materials:

4-chloro-3-fluoroaniline

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate

Downstream raw materials:

2-amino-5-chloro-4-fluoro-benzonitrile

(2-amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone

(E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

1-(4-chloro-5-fluoro-2-iodophenyl)-1H-tetrazole

Refernces

• 1、 -. "NEW ARYL-QUINOLINE DERIVATIVES". Page/Page column 168. . Retrieved 2013/05/22.
• 2、 -. "SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS". Paragraph 00237. . Retrieved 2013/04/25.