3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

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Chemical Name:3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide
CAS No.:1616385-69-3
Molecular Formula:C₂₂H₂₄N₈O
Molecular Weight:416.486
Hs Code.:

Synonyms:3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

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Chemical Property of 3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

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Technology Process of 3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

There total 6 articles about 3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1616387-14-4
tert-butyl 4-[3-[5-[(3,4-dimethyl-1H-pyrazole-5-carbonyl)amino]-1H-pyrazolo[3,4-b]pyridin-3-yl]phenyl]piperazine-1-carboxylate

: 1616385-69-3
3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃;

Reference yield:

: 1616388-22-7
tert-butyl 4-[3-(5-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl]piperazine-1-carboxylate

: 1616385-69-3
3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 20 °C

1.2: 48 h / 20 °C

2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 1186608-83-2
3-bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine

: 1616385-69-3
3,4-dimethyl-N-[3-(3-piperazin-1-ylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; acetonitrile / 3.17 h / 120 - 150 °C / Microwave irradiation

2.1: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 20 °C

3.2: 48 h / 20 °C

4.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;