4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Base Information

Chemical Name:4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide
CAS No.:1436422-32-0
Molecular Formula:C₂₁H₂₂ClF₅N₄O
Molecular Weight:476.877
Hs Code.:

Synonyms:4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

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Chemical Property of 4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

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Technology Process of 4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

There total 13 articles about 4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436426-38-8
4-((tert-butoxycarbonylamino)methyl)-2,3-difluorobenzoic acid

: 1436422-32-0
4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: 4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; 4-((tert-butoxycarbonylamino)methyl)-2,3-difluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

With hydrogenchloride; In 1,4-dioxane; for 5h;

Reference yield:

: 1449693-12-2
C₂₆H₃₀ClF₅N₄O₃

: 1436422-32-0
4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 5h;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436422-32-0
4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 12 h

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol;