(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

Base Information

Chemical Name:(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester
CAS No.:288101-10-0
Molecular Formula:C₂₅H₂₀F₂INO₂
Molecular Weight:531.341
Hs Code.:

Synonyms:(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

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Chemical Property of (Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

Chemical Property:

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Technology Process of (Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

There total 4 articles about (Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81167-39-7
methyl N-(diphenylmethylene)glycinate

: 288101-06-4
1-((Z)-3-Bromo-1-iodo-propenyl)-2,4-difluoro-benzene

: 288101-10-0
(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 20 ℃;
DOI:10.1016/S0040-4039(01)00353-7

Reference yield:

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 288101-10-0
(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CuI; Et₃N / Pd(PPh₃)4

2: Red-Al; I₂ / diethyl ether

3: PBr₃ / CH₂Cl₂ / 0 °C

4: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C

With copper(l) iodide; iodine; phosphorus tribromide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 1: Sonogashira coupling;
DOI:10.1016/S0040-4039(01)00353-7

Reference yield:

: 288100-99-2
3-(2,4-difluorophenyl)-2-propyn-1-ol

: 288101-10-0
(Z)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-iodo-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: I₂; Red-Al / diethyl ether

2: PBr₃ / CH₂Cl₂ / 0 °C

3: LDA / diethyl ether / 0 °C

With iodine; phosphorus tribromide; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide; In diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(01)00253-0