{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester
CAS No.:204513-85-9
Molecular Formula:C₃₉H₆₂N₂O₆Si
Molecular Weight:683.017
Hs Code.:

{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

Synonyms:{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

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Technology Process of {3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

There total 9 articles about {3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79677-60-4
(S)-N-benzyloxycarbonyl-3-(4-hydroxy-3-iodophenyl)alanine methyl ester

: 204513-85-9
{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Heating

2: Et₃N, (PPh₃)2PdCl₂, CuI / acetonitrile / 4 h / Ambient temperature

3: H₂, AcOH / 5percent Pd/C / methanol / 16 h / 2585.7 Torr

4: N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

5: 1 M LiOH / tetrahydrofuran / 1.5 h / Ambient temperature

6: BH₃ / tetrahydrofuran / 2 h / -5 - 10 °C

7: imidazole, N-methylmorpholine / acetonitrile / 2.5 h / 60 °C

With 4-methyl-morpholine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; copper(l) iodide; borane; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm980001q

Reference yield:

: 79677-58-0,122908-62-7
2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride

: 204513-85-9
{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) N-methylmorpholine / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, from 10 deg C to RT, 3 h

2: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Heating

3: Et₃N, (PPh₃)2PdCl₂, CuI / acetonitrile / 4 h / Ambient temperature

4: H₂, AcOH / 5percent Pd/C / methanol / 16 h / 2585.7 Torr

5: N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

6: 1 M LiOH / tetrahydrofuran / 1.5 h / Ambient temperature

7: BH₃ / tetrahydrofuran / 2 h / -5 - 10 °C

8: imidazole, N-methylmorpholine / acetonitrile / 2.5 h / 60 °C

With 4-methyl-morpholine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; copper(l) iodide; borane; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm980001q

Reference yield:

: 204513-78-0
(S)-2-Benzyloxycarbonylamino-3-[4-(2-cyclohexyl-ethoxy)-3-iodo-phenyl]-propionic acid methyl ester

: 204513-85-9
{3-[5-[(S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-(2-cyclohexyl-ethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N, (PPh₃)2PdCl₂, CuI / acetonitrile / 4 h / Ambient temperature

2: H₂, AcOH / 5percent Pd/C / methanol / 16 h / 2585.7 Torr

3: N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

4: 1 M LiOH / tetrahydrofuran / 1.5 h / Ambient temperature

5: BH₃ / tetrahydrofuran / 2 h / -5 - 10 °C

6: imidazole, N-methylmorpholine / acetonitrile / 2.5 h / 60 °C

With 4-methyl-morpholine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; copper(l) iodide; borane; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm980001q