1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

Base Information

Chemical Name:1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine
CAS No.:138154-84-4
Molecular Formula:C₁₉H₂₆Cl₂N₂O
Molecular Weight:369.334
Hs Code.:

Synonyms:1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

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Chemical Property of 1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

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Technology Process of 1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

There total 5 articles about 1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130605-98-0
1-(2-piperidinylcarbonyl)pyrrolidine

: 138154-84-4
1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 3.5 h / -50 - 20 °C

2: 1.) n-BuLi, i-Pr₂NH, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / 1.) THF, hexane, -60 deg C, 1.5 h, 2.) THF, hexane, a.) -60 deg C, 1 h, b.) RT, 1 h

3: 100 percent / H₂ / 5percent Pd/C / ethanol / 24 h / 760 Torr / Ambient temperature

4: 92 percent / LiAlH₄ / diethyl ether / 6 h / Heating

5: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 22 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; n-butyllithium; hydrogen; triethylamine; diisopropylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00081a009

Reference yield:

: 138284-43-2
phenylmethyl 2-(1-pyrrolidinylcarbonyl)-1-piperidinecarboxylate

: 138154-84-4
1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, i-Pr₂NH, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / 1.) THF, hexane, -60 deg C, 1.5 h, 2.) THF, hexane, a.) -60 deg C, 1 h, b.) RT, 1 h

2: 100 percent / H₂ / 5percent Pd/C / ethanol / 24 h / 760 Torr / Ambient temperature

3: 92 percent / LiAlH₄ / diethyl ether / 6 h / Heating

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 22 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; n-butyllithium; hydrogen; diisopropylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1021/jm00081a009

Reference yield:

: 138154-81-1
phenylmethyl 2-methyl-2-(1-pyrrolidinylcarbonyl)-1-piperidinecarboxylate

: 138154-84-4
1-<(3,4-dichlorophenyl)acetyl>-2-methyl-2-(1-pyrrolidinylmethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 5percent Pd/C / ethanol / 24 h / 760 Torr / Ambient temperature

2: 92 percent / LiAlH₄ / diethyl ether / 6 h / Heating

3: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 22 h

With lithium aluminium tetrahydride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1021/jm00081a009