2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine

Base Information

• Chemical Name: 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine
• CAS No.: 97290-04-5
• Molecular Formula: C₂₃H₂₄Cl₂N₄O₆
• Molecular Weight: 523.373
• Mol file: 97290-04-5.mol

Synonyms:2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine

Chemical Property of 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine

There total 10 articles about 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

guanidine hydrochloride (50-01-1) + ethyl 4-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>acetoacetate (97290-03-4) → 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine (97290-04-5)

Guidance literature:

With 2,6-dichloro-benzonitrile; In ethanol; for 5.5h; Heating;

DOI:10.1021/jm00130a026

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) → 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine (97290-04-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) NaH / 1) THF, oil, ice cooling, 2) THF, 16 h

2: 1) piperidine / 1) 2-propanol, 24 h, 2) 4 d

3: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

4: 1) Triton B / dimethylsulfoxide

5: 1) Et₂NH, 2) H₂O, AcOH / 1) THF, 1.5 h, 2) 6 h

6: 63 percent / DBN / ethanol / 5.5 h / Heating

With piperidine; n-butyllithium; 2,6-dichloro-benzonitrile; water; N-benzyl-trimethylammonium hydroxide; sodium hydride; acetic acid; diethylamine; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00130a026

Reference yield:

2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid (90445-15-1) → 2-amino-6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxypyrimidine (97290-04-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 63 percent / DBN / ethanol / 5.5 h / Heating

With 2,6-dichloro-benzonitrile; In ethanol;

DOI:10.1021/jm00130a026

upstream raw materials:

guanidine hydrochloride

ethyl 4-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>acetoacetate

ethyl (2-chloroaceto)acetate

1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne