bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

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Chemical Name:bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate
CAS No.:1541167-61-6
Molecular Formula:C₃₁H₃₄Cl₆N₄O₈Si
Molecular Weight:831.436
Hs Code.:

bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Synonyms:bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

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Technology Process of bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

There total 6 articles about bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1541167-36-5
(4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1541167-61-6
bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate; thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 80 ℃; for 0.166667h; Inert atmosphere;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 1.25h; Inert atmosphere;
DOI:10.1021/ja411950n

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1541167-61-6
bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

4.1: dichloromethane / 10 h / Reflux; Inert atmosphere

5.1: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

6.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 80 °C / Inert atmosphere

6.2: 1.25 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja411950n

Reference yield:

: (4R)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-2-ol

: 1541167-61-6
bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

2.1: dichloromethane / 10 h / Reflux; Inert atmosphere

3.1: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 80 °C / Inert atmosphere

4.2: 1.25 h / 0 - 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In dichloromethane; cyclohexane; acetonitrile;
DOI:10.1021/ja411950n