2-(4-Fluorophenoxy)-1-ethanamine(HCl)

Base Information

• Chemical Name: 2-(4-Fluorophenoxy)-1-ethanamine(HCl)
• CAS No.: 263409-81-0
• Molecular Formula: C₈H₁₀FNO*ClH
• Molecular Weight: 191.633
• Hs Code.: 2922299090
• Mol file: 263409-81-0.mol

Synonyms:Ethanamine,2-(4-fluorophenoxy)-, hydrochloride (9CI);2-(4-Fluorophenoxy)ethylaminehydrochloride;

Chemical Property of 2-(4-Fluorophenoxy)-1-ethanamine(HCl)

Chemical Property:

• Vapor Pressure: 0.00251mmHg at 25°C
• Melting Point: 213-215°C (Expl.) ref.
• Boiling Point: 282.8oC at 760 mmHg
• Flash Point: 124.8oC
• PSA: 35.25000
• LogP: 2.66550
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Fluorophenoxy)ethanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): symbol X ref. Details
• Hazard Codes: symbol X ref. Details

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Fluorophenoxy)-1-ethanamine(HCl)

There total 5 articles about 2-(4-Fluorophenoxy)-1-ethanamine(HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

tert-butyl (2-(4-fluorophenoxy)ethyl)carbamate (263409-78-5) → 2-(4-fluorophenoxy)ethan-1-amine hydrochloride (263409-81-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 18h;

Reference yield: 65.0%

2-(4-fluorophenoxy)acetonitrile (24115-20-6) → 2-(4-fluorophenoxy)ethan-1-amine hydrochloride (263409-81-0)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 16h;

Reference yield:

2-(4-fluorophenoxy)acetonitrile (24115-20-6) → 4-Fluorophenol (371-41-5) + 2-(4-fluorophenoxy)ethan-1-amine hydrochloride (263409-81-0)

Guidance literature:

With hydrogen; platinum(IV) oxide;

DOI:10.1016/j.tetlet.2006.04.149

upstream raw materials:

tert-butyl (2-(4-fluorophenoxy)ethyl)carbamate

2-(4-fluorophenoxy)acetonitrile

2-(4-fluorophenoxy)-ethylbromide

4-Fluorophenol