24115-20-6

Usage

Uses

Used in Organic Synthesis:
2-(4-Fluorophenoxy)acetonitrile is used as a building block in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure allows for the creation of a wide range of compounds with diverse applications.
Used in Medicinal Chemistry and Drug Development:
Due to its distinctive properties, 2-(4-Fluorophenoxy)acetonitrile is utilized in the field of medicinal chemistry and drug development. It may contribute to the discovery and synthesis of new therapeutic agents with improved efficacy and selectivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(4-Fluorophenoxy)acetonitrile is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can potentially enhance the pharmacological properties of the final drug product.
Used in Agrochemical Industry:
2-(4-Fluorophenoxy)acetonitrile is also employed in the agrochemical industry, where it serves as a precursor for the development of new pesticides and other agrochemicals. Its unique structure may contribute to the creation of more effective and environmentally friendly products.

InChI:InChI=1/C8H6FNO/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,6H2

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 590-17-0 cyanomethyl bromide 
• 371-41-5 4-Fluorophenol 
• 624-75-9 iodoacetonitrile 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 121361-56-6 α-(4-fluorophenoxy)-2,4-dihydroxyacetophenone 
• 371-41-5 4-Fluorophenol 
• 263409-81-0 2-(4-fluorophenoxy)ethan-1-amine hydrochloride 
• 6096-89-5 2-(4-fluorophenoxy)-1-ethylamine 
• 370071-62-8 1-(2,4-dihydroxy-5-methylphenyl)-2-(4-fluorophenoxy)ethanone 
• 1532534-43-2 1-(2,4-dihydroxy-5-propylphenyl)-2-(4-fluorophenoxy)ethanone 
• 35370-93-5 2-(4-Fluoro-phenoxy)-thioacetamide 
• 137988-09-1 Acetic acid 3-(4-fluoro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 124330-34-3 3-(4-Fluoro-phenoxy)-7-hydroxy-chromen-4-one 
• 121361-60-2 3-(4-fluorophenoxy)-7-(tetra-O-acetyl-β-D-glucopyranosyloxy)chromone 
• 121377-35-3 α-(4-fluorophenoxy)-2-hydroxy-4-(tetra-O-acetyl-β-D-glucopyranosyloxy)acetophenone 

Relevant academic research and scientific papers

Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile

A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.

Imidazo-substituted compounds as p38 kinase inhibitors

The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.