24115-20-6

Basic information

• Product Name: 2-(4-FLUOROPHENOXY)ACETONITRILE
• Synonyms: 2-(4-FLUOROPHENOXY)ACETONITRILE;2-(4-fluorophenoxy)ethanenitrile
• CAS NO: 24115-20-6
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• Mol File: 24115-20-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 151.1
• Boiling Point: 258.1 °C at 760 mmHg
• Flash Point: 109.9 °C
• Appearance: /
• Density: 1.185 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-(4-FLUOROPHENOXY)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENOXY)ACETONITRILE(24115-20-6)
• EPA Substance Registry System: 2-(4-FLUOROPHENOXY)ACETONITRILE(24115-20-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 24115-20-6(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenoxy)acetonitrile is a chemical compound with the molecular formula C8H6FNO. It is a nitrile derivative with a fluorophenoxy group attached to the acetonitrile moiety. 2-(4-FLUOROPHENOXY)ACETONITRILE is used in organic synthesis and can act as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It may also have potential applications in the field of medicinal chemistry and drug development due to its unique structure and properties. However, the compound should be handled and used with caution, as it may have potential health and safety hazards, and proper precautions should be taken when working with it.

InChI:InChI=1/C8H6FNO/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,6H2

Upstream product

• 371-41-5 4-Fluorophenol 
• 107-14-2 chloroacetonitrile 
• 1765-93-1 4-fluoroboronic acid 
• 590-17-0 cyanomethyl bromide 
• 624-75-9 iodoacetonitrile 

Downstream Products

• 121361-56-6 α-(4-fluorophenoxy)-2,4-dihydroxyacetophenone 
• 370071-62-8 1-(2,4-dihydroxy-5-methylphenyl)-2-(4-fluorophenoxy)ethanone 
• 1532534-43-2 1-(2,4-dihydroxy-5-propylphenyl)-2-(4-fluorophenoxy)ethanone 
• 35370-93-5 2-(4-Fluoro-phenoxy)-thioacetamide 
• 137988-09-1 Acetic acid 3-(4-fluoro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 124330-34-3 3-(4-Fluoro-phenoxy)-7-hydroxy-chromen-4-one 
• 121361-60-2 3-(4-fluorophenoxy)-7-(tetra-O-acetyl-β-D-glucopyranosyloxy)chromone 
• 121377-35-3 α-(4-fluorophenoxy)-2-hydroxy-4-(tetra-O-acetyl-β-D-glucopyranosyloxy)acetophenone 
• 263409-81-0 2-(4-fluorophenoxy)ethan-1-amine hydrochloride 
• 263409-78-5 tert-butyl (2-(4-fluorophenoxy)ethyl)carbamate 
• 6096-89-5 2-(4-fluorophenoxy)-1-ethylamine 

Relevant articles and documents

Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile

A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

Imidazo-substituted compounds as p38 kinase inhibitors

The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.